Abstract
Backgrounds and Objectives: Mineral trioxide aggregate as one of the root-end filling materials has excellent biocompatibility. Two different compositions of white and gray MTA were manufactured by Iranian and foreign companies. The aim of this study was to compare histopathological reaction to Iran made and foreign gray MTA in connective tissue of rat.
Materials and Methods: Forty rats were divided in to 5 groups of 8. The polyethylene tubes were filled with foreign, Iran made gray MTA and empty ones implanted in subcutaneous connective tissues. The samples were examined histopathologically after 7, 15, 30, 60 and 90 days and were scored as followings: 0, without inflammatory cells; without inflammatory reaction. 1, less than 25 inflammatory cells; mild inflammatory reaction. 2, 25 to 125 inflammatory cells; moderate inflammatory reaction.3, more than 125 inflammatory cells; severe inflammatory reaction. Kruskal-Wallis and two way ANOVA were used for statistical analysis with a significance level of P<0.05.
Results: Overall, inflammatory reactions were reduced in all groups gradually. Experimental groups had moderate to severe inflammation in 7 days interval which had significant difference with the control group having mild to moderate inflammation (P=0.04). There were no significant differences between experimental groups and control group in other intervals (P>0.05).
Conclusion: Cellular inflammatory reaction of subcutaneous connective tissue of rat to Iran and foreign made gray MTA were similar.