Abstract
Background and Objectives: Many studies have been suggested that element's of soy extract can improve learning and memory and delay the onset of neurological disorders such as, Alzheimer's disease. However, there are a few investigation on the effects of total soy extract. So we studied the effect of total soy extract on spatial memory.
Materials & Methods: In this study 30 female rats were allocated randomly to 3 groups: 1) sham (surgery without ovariectomy, 2) ovariectomized (OVX), and 3) treatment (OVX and Soy gavage). The animals of treatment group received 60 mg/kg per day total soy extract in drinking water for six weeks. Statistical analysis was performed using one way ANOVA (Tukey) test and SPSS software.
Results: The results showed that ovariectomy impaired spatial memory (P<0.05) and oral administration of total soy extract ameliorated learning and spatial memory deficits of OVX rats.
Conclusion: This study indicated that ingestion of total soy extract had positive effect on spatial memory especially in OVX rat.