Medical Journal of Tabriz University of Medical Sciences and Health Services

Medical Journal of Tabriz University of Medical Sciences and Health Services. 2020;42(2): 194-199.
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Original Article

The response of BAX, BCL-2 ratio to vitamin D consumption with concurrent training in rat males

samad safarzadeh gargari 1* ORCID logo, hassan matin homaei 2 ORCID logo, mohamad ali azarbayjani 2 ORCID logo

1 Student of Exercise Physiology, Department of Exercise Physiology , Faculty of Physical Education and Sport Science, Tehran Islamic Azad University, Central Branch, Tehran, Iran
2 Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Tehran Islamic Azad University, Central Branch, Tehran, Iran
*Corresponding author; E-mail: safarzadeh.gargari@yahoo.com

Abstract

Background: Previous studies has been indicated that vitamin D regulate apoptosis of myocardial, and improve cardiac performance But this mechanism has been remain unclear. The aim of this study was the response of BAX, BCL-2 ratio to vitamin D consumption with concurrent training in rat males.

Methods: 50 male’s rats were randomly assigned to 5 groups with 10 rats in which group. Groups include of: 1-control Group (C), 2- vitamin D, group (D), 3-exercise group (E), 4-exercise+vitamin D group (ED), and 5- d methyl sulfoxide + salin group (M). Exercise groups have been ran on treadmill for 8 weeks in every days with specific speed and incline. 24 hr after last exercise and in anesthetic state all rats have been knockouted to determine bax and bcl2 proteins ratio. For measuring the BAX and BCL-2 proteins were used by ELISA technic.

Results: The amount of protein in E+D group was more decreased in compared to other groups but no significant difference has been observed in between groups (p=0.138). Also there was little altered in BCL-2 and BAX/BCL-2 ratio in E and D groups compared to control and placebo groups (P>0/05).

Conclusion: The eight weeks concurrent training with vitamin D supplementation had no effect on BAX/BCL-2 protein ratio in rats, and to some extent can prevent the myocardial apoptosis process via Bax/Bcl-2 ratio regulating.

Keywords: Cardiac Cell Apoptosis, BAX, BCL-2 Protein Ratio, Vitamin D Supplementation, Concurrent Training, Rat
How to cite this article: Safarzadeh Gargari S, Matin Homai H, Azarbayjani M A. [The response of BAX,BCL-2 ratio to vitamin D consumption with concurrent training in rat males]. Med J Tabriz Uni Med Sciences Health Services. 2020 June- July; 42(2):194-199. Persian.
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Submitted: 27 May 2018
ePublished: 19 May 2020
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