Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 35 3 2013 08 05 Effect of Helicobacter Pylori Eradication on Clinical Symptoms in Gastroesophageal Reflux Disease 54 59 EN Mohammad Hossein Somi Parinaz Kanani Mohammad ali Hossein nezhad Journal Article 2012 11 06 2013 02 12 Backgrounds and Objectives: Gastroesophageal reflux disease is one of the most prevalent gastrointestinal disorders and the relationship between GERD and H. pylori is complex and effect of H. pylori eradication on GERD is controversies. The aim of study is to evaluate the effect of H. pylori eradication on GERD symptoms. Materials and Methods: In an interventional, before-after study, of 200 patients with chronic dyspepsia and positive H. pylori infection confirmed by rapid urea test or histology and underwent a 2 weeks period of quadruple anti-Helicobacter therapy and a subsequent 6 weeks of pure anti-acid therapy. Eradication's success was assessed based on urea breath test result at least 2 weeks after anti-acid cease, and the second validated symptom questionnaire then was filled out which contained the same questions as the first one. A validated symptom questionnaire about probable symptoms of GERD also filled. Results: GERD's symptoms (Regurgitation, Heart burn) were increased in the eradication group.(heart burn:16% to 32% p=0.03),(regurgitation 13.6% to 15% p=0.04). Retrosternal pain was meaningfully decreased (36% to 29% p=0.04). Wheeze (1.4% to 0.5% p=0.03) and hoarseness (1.5% to 0.6 %p=0.03) had meaningful decrease. Conclusion: H. pylori eradication has variable effect on GERD's symptoms are infected individuals.