Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 35 3 2013 08 05 The Effect of Testosterone Enanthate on Plasma Levels of Cholesterol, Triglyceride, HDL, VLDL, and LDL in Male Rats 18 25 EN Hadi Andishmand Rastgar Olfati Karaji Afshin Darosaz Tabrizi Shokoofeh Farshadyan Hashem Andishmand Journal Article 2013 01 19 2013 04 11 Backgrounds and Objectives: Testosterone Enanthate Analog (Testosterone Enanthate: TE) is used by athletes to increase muscle size and strength and also in patients with low plasma testosterone levels. Studies show that high levels of testosterone may affect the plasma lipid profiles. The purpose of this study was to evaluate the effect of supraphysiological dose of TE injection on plasma levels of total cholesterol, triglycerides, very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) of adult male rats. Materials and Methods: In this study, 35 Wistar rats were randomly divided into 5 groups, each group consisted of seven rats: In Group I- Gonadectomized rat group received 5 mg/100 g body weight of TE; Group II- Not gonadectomized rat received 5 mg/100 g body weight of TE; Group III- gonadectomized rat received 0.5 ml olive oil; Group IV - Not gonadectomized rat received 0.5 ml olive oil; and Group V- Control group (intact rats not receiving any supplement). 60 days after receiving supplements, plasma levels of cholesterol, triglyceride, HDL and LDL were measured. Results: No significant difference in plasma cholesterol concentrations was found between different groups. Plasma triglyceride levels were significantly different in groups I (P< 0.001) and II (P< 0.05) and plasma VLDL levels in group I (P< 0.001) and II (P< 0.01) compare to it’s control group. No significant differences were found between groups I and II in the plasma LDL lipoprotein levels compare to the control group, but HDL levels decreased in group II compared to the control group (P< 0.05). Conclusion: TE consumption increased plasma levels of triglycerides and VLDL and decreased HDL levels; hence, the risk of cardiovascular disorders is higher in the people who receiving TE compare to others.