Tabriz University of Medical Sciences Medical Journal of Tabriz University of Medical Sciences 2783-2031 42 6 2021 02 24 Effect of eight weeks of regular aerobic exercise on apolipoprotein AI gene expression and lipid profile indices in obese women 773 780 10.34172/mj.2021.019 EN Solmaz Babaei Bonab https://orcid.org/0000-0003-0185-7850 Bahram Jamali Gharakhanlou https://orcid.org/0000-0002-3138-273X Journal Article 10.34172/mj.2021.019 2019 06 24 Background: Heart disease is a multifactorial disease with genetic background and environmental factors involved. And new studies believe that markers such as apolipoprotein AI are a better criterion for diagnosis. Therefore, the purpose of this study was to investigate the effect of eight weeks of regular aerobic exercise on apolipoprotein AI gene expression and lipid profile indices in obese women. Methods: In this experimental study, 30 healthy obese women aged 35-30 years were randomly selected and divided into control (n =15) and experimental (n =15) groups. The experimental group underwent 8 weeks of regular aerobic exercise at 60-75% of the heart rate reserve three sessions per week for 60 minutes each session. Apolipoprotein AI mRNA expression was measured by Semi-quantitative-RT-PCR method and lipid profiles were measured in both pre-test and post-test. Results: The apolipoprotein AI gene expression was significantly increased in the experimental group compared to the control group (P<0.05). Also, TG (P = 0.003), TG LDL in the experimental group showed a significant decrease compared to the control group and HDL level in the experimental group was significantly higher than the control group (P = 0.001) Conclusion: The regular aerobic exercise has an important role in reducing cardiovascular diseases through increasing apolipoprotein AI gene expression and improving lipid