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Med J Tabriz Uni Med Sciences. 2022;43(6): 515-524.
doi: 10.34172/mj.2022.004

Scopus ID: 85131555372
  Abstract View: 905
  PDF Download: 387

Nervous System

Original Article

Evaluation of the anticonvulsant effect of carvacrol in Pentylenetetrazole (PTZ)-induced seizures in male mice: N-Methyl-D-Aspartic Acid receptor role

Hossein Amini-khoei 1 ORCID logo, Shakiba Nasiri Boroujeni 1 ORCID logo, Zahra Lorigooini 1 ORCID logo, Sepideh Yadollahi 1, Seyyed Kamal Solati Dehkordi 1 ORCID logo, Mahmoud Rafieian Koopai 1* ORCID logo

1 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: Email: rafieian@yahoo.com

Abstract

Background. Epilepsy is one of the most common neurological disorders after stroke. Due to the side effects and poor response of conventional anticonvulsant drugs, researchers have turned their attention to find new drugs. Carvacrol is a phenolic compound with neuroprotective, anti-inflammatory, antioxidant and anticonvulsant effects. The aim of the study was to investigate the anticonvulsant effects of carvacrol in PTZ-induced seizures in male mice and to investigate the role of N-Methyl-D-Aspartic Acid (NMDA) receptor.

Methods. In the present experimental study, 90 mice were randomly divided into 9 groups (n=10). Drugs were injected intraperitoneally 30 minutes before PTZ injection. Then, seizure onset time, serum and brain antioxidant capacity (TAC) and malondialdehyde (MDA) and NMDA receptor gene expression in the hippocampus were examined.

Results. Seizure onset time in the group received carvacrol (20 and 40 mg/kg) was significantly longer than the PTZ group (P<0.05). Treatment with carvacrol (20 and 40 mg/kg) significantly increased serum and brain antioxidant capacity and reduced serum and brain MDA in compared to the PTZ group (at doses of 5, 10, 20 and 40 mg/kg). The expression of NR2A and NR2B subunits of hippocampal NMDA receptors in carvacrol-received mice was significantly lower than the PTZ group (P<0.05).

Conclusion. Carvacrol has anticonvulsant effects, possibly by inhibiting oxidative stress and reducing the expression of subunits of NMDA receptors.


How to cite this article: Amini-Khoei H, Nasiri Boroujeni Sh, Lorigooini Z, Yadollahi S, Solati Dehkordi S.K, Rafieian Koopai M. The anticonvulsant effect of carvacrol in Pentylenetetrazole induced seizures in male mice: n-methyl-d-aspartic acid receptor role. Med J Tabriz Uni Med Sciences. 2022;43(6):515-524. doi: 10.34172/mj.2022.004. Persian.
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Submitted: 13 Feb 2021
Revision: 12 Jul 2021
Accepted: 14 Jul 2021
ePublished: 12 Jan 2022
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